Alchy is often a problem. You can normally only send one item per person per 8-hour cycle. When you log in, do all the clicks you can, then send the ones in your box and you can send 2 that cycle. Also there is a limit on how many items you can send which depends on your alchemist building and your title (the higher your title the more you can send). I have just started playing in Heph and found that I could send 10 items before I even had an alchemy building, my title is Duke.
Alchemy is still a bit of a mystery at times, but I am working on solving it. I think that any requests that don't get fulfilled in the first 24 hours disappear and you have to ask again - extremely frustrating!