I read through the whole thread to see if anyone else had any of the same ideas I did, and there are so many more cool ideas I didn't even think of!
I am going to second, third, fourth or whatever suggestions for:
Asterix and Obelix
Discworld
Hitchhiker's Guide to the Galaxy
and Star Wars
I know there was an older story based on Lord of the Rings, but how about one for the Hobbit?
Game of Thrones, but a "cleaned up" version without all the sex and violence...and maybe a different ending?
Anything based on classic, or "old school" anime like Robotech, Star Blazers/Yamato, or Captain Harlock.
Godzilla/Mothra/King Ghidora and any of the other Giant Monsters
Any and all of the well-known fairy tales. Each mine could cover one fairy tale, or there could be two or three events covering a few fairy tales each.
Harry Potter (unless there's been one already, and I missed it?)
Star Trek...but it would be funniest if it was the "old school" style, with a Captain that keeps breaking the rules (but with good intentions!) and lots of friends who just happen to be female...but not, you know, "girlfriends."
Elfquest was an awesome set of comics and novels that would be fun to play through.